Added Value on Sade Village and Bau Nyale Festival in Autoimmune Diseases Immunization Travel: Supported by Aptamers Technology
Abstract
Prevalence of Autoimmune diseases (AD) are high in developed countries and low in developing countries. Wall of worm were associated with lower level of allergy and support the hygiene hypothesis (HyHy). Long term use of Interferon as drug for ADand synthetic vaccine made by epitope mapping are global economic burden. Adolescence from developed countries traveling to Ghana forwarding AD-HyHy. Fecal microbiota transplantation (FMT) for fighting ADhave been developed in hygiene countries such as UK, Japan and Korea, meanwhile the aims of this study are reveal an added value to Sade village 'FMT culture' and Bau Nyale/Mandalika Princess festival for Nature Vaccination on AD. These local nature vaccination needs to be known by policy maker and political doer and could be a translational-medicine education topic to lessen ADeconomic global burden. Method: Systematic-review and Bayesian network analysis. EBSCO host search engine were used. Result: Description of 9 Publications of meta-analysis are chosen. Conclusions: The increasing of immunity in developing countries and decreasing in clean habit educated family is based on hygiene hypothesis, could be answered by local life-style and festival. These added value for local tour package has been supported by affimers and aptamers contemporary technology based on bacteria and worm epitope mapping.
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Introduction
Wall of worm cell have many epitope as well dormant bacteria (Fecal Microbiota Transplantation or FMT),1,-5 is now locally neglected and globally abandoned. Usage of natural antigen for vaccination is hygiene hypothesis (HyHy) based on prevention such as in allergy epidemic in US.6-8 Decreasing autoimmune disease (AD) by natural ADvaccination as added value of Sade and Bau Nyale festival, could lessen ADburden. Meta-analysis on Rheumatoid Arthritis (RA) molecule has ethnicity relation9 parallel with new loci RA in Japan10,11 and Korean and European eight new RArisk loci.11 Meta-analysis on FMT in IBD12 .and hygiene lifestyle are associated with allergic, atopic sensitization,7 and asthma. Hand vs. machine dishwashing have significantly different ADprevalence.13 A number of references show that ADand climate14,15 and socioeconomic status14 are related to HyHy.8,16 Do these factors contribute to the occurrence of increasing prevalence of AD in developed countries? Meanwhile, protocols in synthetic vaccine industry for AD or treatment strategies for people with AD, with interferon longterm usage are still unclear. No publication before that summarizes and describes the association of HyHy, AD, FMT, Genome Wide RA,17 RA in developed countries,18-20 Epitope-RA-SLE,21 Helminth-Hygiene-AD,22,23 vaccine-epitope/antigen.22,24-26 Just by implementing local wisdom such as Sade village and Bau Nyale–Mandalika Princes festival can lower risk of AD. Effective preventive activities and treatments could be initiated for high risk person’s ADcaused by clean habit of living.6,13,27-31This prevention and therapy model is the first effective natural vaccination idea published.
Conclusion
Epitope of FMT, dormant bacteria, protein from the wall of worm are all rich of ranges epitopes and could be present in cultural event like Sade village and Bau Nyale ‘Mandalika princess’ festival. These indigenous study from local, present to global is similarly paralleled with epitope mapping and contemporary industrial affimers and aptamers based on epitope biotechnology for diagnostic, vaccination and therapeutic fighting against autoimmune diseases. Further education to policy maker and global politic doer from local to global will support this added value idea.