Aflatoxin B1 Exposure Induced Obesity/Breast Cancer Based in Neighborhood Socioeconomic Status
Abstract
Background: Obesity (Ob) linked to Breast Cancer (BC) has reached epidemic proportions worldwide (WW) including Indonesia, Brazil, Bangladesh and also developed countries. To assess the prevalence and associated risk factors of central Oband BC WW, are commonly linked with geography (wet and warm climate), race, immigrant, but not SES. Problem: Low and middle-SES are associated with lower outcome affect late diagnosis, late hospitalization and treatment, but not with p53 mutation caused by AFB1 exposure.
Objectives: Low and middle-SES and neighborhood are linked to AFB1 exposure as the cause of Ob/BCprevalence. Method: PRISMA design of Systematic Review using Science Direct and EBSCO data based with
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Introduction
Background/Aims: Prevalence Fat distribution due to Brown Adipose Tissue known as UCP2 abundant in Abdominal Adipose Tissue, UCP3 abundant in skeletal muscle, and UCP1 abundant in subscapular fat, is positively related with inflammation marker and the prevalence of Metabolic Syndrome (MS)-associated with pre diabetes, diabetes and its complication such as cardiovascular diseases.1,2,3Problem: Socioeconomic status (SES) are correlated with Ob-BCand Menopausal status (Estrogen),4 neighborhood5 and funding to early diagnostic,6,7 treatment8,9,10and Physical Activity,11,12but Not AFB1 exposure are in the National government project. Socioeconomic change BC in Brazilin this 21 century.13Objective: AFB1 exposure marked by urine AFM1 sub ppb,14,15,16,17 become the infrastructure of the cause and avoidance of SES problem positively related with Ob/BChigh prevalence. AFB1 exposures are well known cause Liver Cancer, but almost never cause Ob/BC. Unlike that SES-associated better fund in early Ob/BCdiagnosis, management, treatment project, a study SES-associated better management in AFB1 exposure in combatting Ob/BC. Abundance data of AFB1-Liver cancer will be useful for Ob/BC.
Conclusion
Not only in wet and warm known as developing countries, but also low and middle SES population in developed (dry and cold) countries, the food and feeds have AFB1 exposure high risk, and this inflammation stuff is the cause of Ob/BChas been masked by estrogen in premenstrual age.
CONFLICT OF INTEREST No Conflict of Interest till the date.
