LGBTQ: The Molecular Mechanism and its Role in Elucidating Proportional for a Better Management
Abstract
Background: LGBTQ is prone high prevalence and has economic, social business grow in wet and warm countries. It becomes political issue Worldwide (Time magazine, June 12, 2017, page 7) in immig ration and also president election campaign in industrial countries in the last decades.
Problem: Current effort from day care psychosocial early predictive and training, better therapy, law in sentence, marriage and immigration/ refugee has become topic of controversies feel not ended. From psychiatry social, transgender operation and hormonal have been the day fact, but not one make it clear from the molecular aspect as the cause, and what to do in prevention, promotion for keeping away from methylation and demethylation affect. This study digs the reference about CGG repeat in large to small DNMT off.
Objective: CGG repeat as the molecular aspect of methylation and demethylation beyond health science should build and known by decision and policy mak er. Controversial are broad, LGBT problem are hug, increasing but attorney denies that gay people exist in their region (Times magazine, June 12, 2017, page 7).
Method : Systematic Review with Bayesian analysis and mathematical model.
Result: flowchart and table of 13 ref from CGG repeat in DNA methylation analysis, 2 Meta -analysis. Small/ grey zone CGG repeat associated with neuropsychiatric risk.
Discussion: Brain and behavior DNMT off functional.
Comparison: Law, neuropsychiatric/early social -educatio n vs. ensure no to methylation and demethylation in wet and warm area.
Outcome : Winning the combat of LGBT prevalence.
Conclusion : Winning the combat of LGBT prevalence not with early psycho -social activity, but with molecular psycho forensic and that is through what cause small/ grey zone CGG repeat prevalence.
Keywords
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Introduction
Molecular aspect approach policy on LGBT high prevalence have never been bring in fighting/ combat it. Behavior problem large to Small CGG repeat LGBT law/psycho -social/MGMT has been reported due to DNMT off gene, DNA Methyl Transferase in brain functional. Street fashion carnival business, club, and cabaret vs. gre y zone and pre mutation CGG repeat that off DNMT and make functional brain and behavior problem has become the channeling of many district governments. Health science intense the early detection in day cares and teaches and train psycho -social activities as prevention to L GBT behavior. Nowadays, Social category label (SCL) and future direction are topics in top executive government authoritarianism.1Brain and behavior gene in mood disorders and in promoter gene in methylation has been reported.2Psychological status of p remutation showing a complex with the size of small CGG repeat (50 -141) which associated with methylation on DNMT.3Premutation (55 -200 CGG repeat) on FMR1 gene and mRNA level reported higher level in obsessive -compulsive symptom and RNA toxic gain -of-function model in a neuropsychiatric phenotype.4 Page | 24 1.1 Background At least, 2 professors from Top Farmer Institute in wet and warm country ask The Constitutional court that LGBT behavior without thinking of their ages, should be sentence maximum 5 years without asking the age, also for 10 years old boys and girls.5While sex party with men striptease caught 149 „men‟ in wet and warm conservative countries on 21/5/2017 in Kelapa Gading,6Orlando nightclub shooting on June 12 2016 with 49 dead are shocking peoples local and global, Jember Fashion Carnival as street Festival every years a re think as a good cultural valve with given satisfied feeling to the district municipal government, while the parents are proud and doesn‟t know about the psychology label next.7In world lev el, Putin and Macron dispute about Gay right in Chechnya.8-Time Magazine - June 12, 2017 p7 -, the Chechnya authorities proclaimed, there is no LGBT cases in their country. Then The Telegraph writes that Angela Merkel urges Vladimir Putin to protect Chechny a gay rights.9 1.2 Problem The issue about LGBTQ has been sharply increased in these days including in Indonesia. Vitriolic critics against LGBTQ keep ongoing as it is thought as morally unacceptable behavior by the community. People considered it as a social crime leading to discrimination in many aspects for the LGBTQ peoples. Government Concern in street fashion carnival, club, cabaret in many wet and warm countries and the state in one hand function as open the valve in the cultural best way, and the other hand neglected grey zone small CGG which off DNMT gene aspect, so that misleading the cause of LGBT and losing one‟s way the change to eradicate what caused of small CGG repeat in plant and human in tropical rainforest wet and warm climate condition. Meanwhile, predispose pr emutation to FXTAS (Fragile X Tremor Ataxia Syndrome ) are associated in the CGG repeat.10 1.3 Objective To socialized this molecular aspects etiology of LGBTQ as a part of LGBTQ management. Aware of micromolecule in LGBT mental: small a mount of CGG repeat -LGBT should be done broadly beyond health department not only by executive, legislative, but also judicative decision maker and policy doer.
Conclusion
The relationship between CGG sequences repeat and LGBTQ will replace discrimination and resulting into appropriate management of LGBTQ whi ch will be elucidating proportionally.
VII. SUGGESTION Awareness to policy maker and decision doer in small CGG repeat.
Government Concern needs this molecular aspect from local Wet and Warm countries present to Global Health Problem.
