SPIONs Weapons by Moringa Oleifera finally improves outcome of Multi-Organ Damages (MODs) Prevention: Fact or hype for Reason behind Fighting High Sepsis Rates
Abstract
Introduction: Spinel ferrite nanoparticles (Superparamagnetic Iron Oxide Nanoparticles/SPIONs) semiconductors have been broadly reported to kill bacteria outside the human body. SPIONs as photocatalytic agents in coloring dye water treatment have different mechanisms, it’s a redox reaction. SPIONs as MRI agents have the same principle as bacteria killer, to emit electromagnetic waves. Winning against the high prevalence of MODs and sepsis is the aim of this study. Method: Review article of Ex/Em SPIONs semiconductor in Photothermal Therapy (PTT).
Result: Table of 16 references which support SPIONs as New Generation (NG) antibiotic to kill resistant bacteria inside the body.
Discussion: Moringa oleifera gold composite NPs vs. NGbeta-lactams. SPIONs green synthesis gold composite NPs are used as photothermal therapy (PTT) based on inducing hyperthermia to kill bacteria inside the body: NG MDR eradication. Conclusion: PTT therapy achieved with SPIONs, under NIR, is used to kill MDR, XDR, TDR micro-bacteria, fungi and cancer cells inside the human body.
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Introduction
Multi organ damages (MODs) is the terminal cases of sepsis. MODs is the highest incidence of all cause of death. Sepsis due to antibiotic resistance is almost the cause of death in all ICU hospital department nowadays. In this 3 decades, new antibiotic continuously found, but could not eradicate the Multi Drugs Resistance (MDR) bacteria inside the body. The using of super paramagnetic iron oxide nanoparticles (SPIONs) which induce hyperthermia to kill bacteria has been reported.1 The using of Ferrite nanoparticles (FNPs) through green synthesis will eradicate all Microbe resistance: MDR, XDR, TDR, inside the human body where body tissue is most transparent to NIR. Shielding by skin melanin, UVkill all resistance bacteria only outside the human body. This study wants to reveal SPIONs green synthesis2 e.g. from Moringa oleifera gold composite NPs used as photothermal therapy (PTT), based on inducing hyperthermia, to kill bacteria inside the body. The New/Next Generation (NG) MDR eradication, after the racing of new generation antibiotics era, is based on it. Excitation/Emission (Ex/Em) SPIONs semiconductors vs. Photocatalytic agents in coloring/dye water treatment2,3 mechanism has been recorded. The mechanism of SPIONs as MRI agent4 VS. SPIONs AuF based on hyperthermia1 to kill bacteria,5 fungi,6,7 cancer cells,8 are the same with SPIONs for NG MDR/XDR/TDR antibiotics bacteria inside the human body.1,5
Conclusion
SPIONs green synthesis gold composite NPs are used as NIR photothermal therapy based on inducing hyperthermia to kill bacteria inside the body: NG MDR bacteria eradication, prevent MODs in sepsis.
