The Role of Mild Thrombocytopenia in mild COVID-19 Infection: A Systematic Review
Abstract
Introduction: The COVID-19 pandemic has caused the deaths of more than 9,122,116 people, mostly elderly and/or comorbid such as diabetes and immunosuppressed state using cortisone. While the quarantine measure is necessary, and pancytopenia happens during the hospitalization, earlier thrombocytopenia is often being implemented to manage DHF patients.
Problem: Patients with comorbid have thrombocytopenia and have been managed as DHF patients. Meanwhile, the cost of the pandemic is not limited to medical-aspect, and the virus has led to psychological-aspect of patients not being hospitalized in special COVID-19 barracks.
Aims: To reveal that thrombocytopenia could be used for COVID-19 diagnosis and as early as possible being managed on COVID-19 treatment management.
Method: Systematic Review with PRISMA Design, using Science Direct search machine and Mendeley My Library, with
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Introduction
Since December 2019, new COVID-19 outbreaks have occurred and spread around the world. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).. This viral pandemic of COVID-19 led to the deaths of over 9,122,116 peoples, mostly elderly or comorbid as diabetes, and immunosuppressed state, using cortisone, and chloroquine treatment.1 Corona virus disease 2019 (COVID-19) is a pandemic which started in China in late 2019 and has now spread across the globe in 2020.2 The clinical characteristics of patients are still unclear. Most patients had fever as the first symptom for admission. Other symptoms included cough, fatigue, hoarseness and diarrhoea. Certain patients did not have fever at the time of consultation, and most were not accompanied by organ damage.3,4 Currently there is limited knowledge on medical comorbidities and COVID-19.5 Clinicians are fighting against this new disease and are focusing on various factors that may lead to better survival outcomes. The common symptoms of COVID-19 infection are fever, cough, myalgia and fatigue.6 There was analysis of patients with COVID-19 had described various clinical characteristics and their association with the severity of disease, lymphopenia and eosinopenia may serve as predictors of disease severity and disease progression in COVID-19 patients, and enhancing the cellular immunity may contribute to COVID-19 treatment. 7,8 While the quarantine measure is necessary and pancytopenia happen during the hospitalization, earlier thrombocytopenia is often implemented of being managed as DHF patients.9, 10,
Conclusion
In facing the COVID-19 pandemic, most countries feel not early to diagnosis mild COVID-19 on doing fast quarantine, which right possible diagnosis could be done by thrombocytopenia alone or parallel with lymphocytopenia. Thus, Thrombocytopenia might become a sentinel of COVID-19, and it serves attention during mild COVID-19 triage. CONFLICT OF INTEREST Nothing
