Vector and Non-Vector Infection up to Nano-Vector in Association with RNAI Transfection
Abstract
Transfection is a translocation of DNA or RNA pieces, which could occur naturally or from human effort through laboratory/pharma results, that is so advanced now. Still the same incidence and prevalence in natural-huge laboratory/ incubator tropical rainforest is neglected as the pathogenesis mechanism on the laden from nano-infection. Nano-vector could deliver 3 different payloads incl. plasmid, mRNA, and RNP for CRISPR/Cas9 genome editing. They were knowing the benefit and disadvantages of transfection in association with the high prevalence of transfection diseases such as gen silencing/ failure in gene expression/ gene blocking/ gene mutation and gene polymorphism. This review article manually using a search engine. First, confirm the difference between the host and vector. Then digging non-vector transfection, nano-carriers, and nanoparticles, in drugs delivery using ‘binahong’ (Anredera cordifolia) leaves which are already used in pharmacies and imaging diagnostics. Lipid nanoparticle, the first siRNA drug deliver. Ferrite Nickel (NiFe2O4) synthesis, and CoFe2O4 nanoparticle synthesis using ‘binahong, kelor, salam’, etc. leaves extraction, also are nowadays nano-carriers. Meanwhile, the main class of vector viruses which had been tested for clinical application, incl. retroviruses (RV), adenoviruses (AV), adeno-associated viruses (AAV), lentivirus (LV), and herpes simplex viruses (HSV). Vector viruses, plasmid, mRNA, RNAi, and Lipid, polymer, or inorganic composition, which are used for drugs, could occur in nature. This study concluded that RNAi for nowadays drugs and Next Generation (NG) Pharma, occurrences, exist in the laboratory, at home, and in the garden, and naturally.
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Introduction
The high prevalence of transposon (nanomolecule) transfection in tropical rainforests incl. Indonesia and India are not watching out for the vector aspect in the prevention and promotion application so specific character is neglected. Singapura and Japan has solved DHF by making big water tunnels so that there is no puddle at the beginning and the end of rainy season. Indonesia solves DHF by buying vaccines and doing fogging which is vulnerable to becoming pesticide resistant. This study aims to look over the information about vector dan non-vector transmission of transposon/ virus to humans.
Efficient and effective prevention and promotion with parsimony spirit.
Focus on diseases caused by CGG-repeat1,2,3,4 and sepsis.5 is now a usual occurance so that almost cases in primary care and ICU could find these patients. Macro- (parasite), micro- (bacteria) and nano- (virus) infection in meter measurement have patients which are not known as infectious diseases, but as proteomic and metabolomic failures. Abnormality such as Parkinson Syndrome, Autism, Bipolar, and other brain diseases, also mental and behavioral, and social disorders, are faraway from infectious and are known as non-communicable diseases, which are separated from infectious diseases. Several cases are broadly known caused by pesticide use.4 This study appoints these cases as transposon transfection from the vector and non-vector aspect.
The aims of this study is the prevention and promotion of vector and non-vector chains related to countermeasures nano-infection in the tropical rainforest areas.
Conclusion
Prevention and promotion of vector chain and non-vector chain associated the countermeasures nano-transfection in tropical rainforest with the effect silencing/blocking the genes, has already reported and described for the first time opportunity. RNAi for nowadays treatment Next Generation (NG) pharma could occur in the laboratory, at home, and in the garden in nature.
